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Deroofing: a tissue-saving surgical technique for the treatment of mild to moderate hidradenitis suppurativa lesions

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Oxidative stress affects numerous molecular pathways, including inhibition of the cystine/glutamate antiporter system, decreased expression of GPX4, disruption of iron homeostasis and lipid peroxidation, which is a major driver of ferroptosis activation (54)

Second, proteostasis disruption involves declined autophagylysosomal and ubiquitinproteasome activity, rendering proteins like syn prone to aggregation and resistant to clearance [62]