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Description
Since the discovery of the first xCT inhibitor erastin [80], derivatives like imidazole ketone erastin (IKE) was developed to improve solubility meanwhile introducing lysine-reactive ketone as a covalent warhead, thereby achieving nanomolar IC 50 [81,82]

validation, R.D.R., D.M., S.F
[DOI] [PubMed] [Google Scholar] Gupta I., Adin S.N., Mohd Aqil, Mohd Mujeeb

Epidemiological investigations have demonstrated that quercetin can reduce the risk of T2DM (124127)

Inhibition of the IRE1 pathway has demonstrated substantial therapeutic potential
