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10.3390/ph17010054 45 ForsterA

doi:10.5603/ep.95639

Int J Eat Disord 2015;48(7):826-841

Adoptive cell therapy (ACT) using activated CD8 + T cells with genetic deletion of GPX4 also failed to enable antitumor immunity and subsequent tumor control

Under normal oxygen conditions, EGLNs hydroxylate the HIF subunit, which facilitates its interaction with the von Hippel-Lindau E3 ubiquitin ligase complex and ultimately leads to the proteasome degradation of the HIF subunit
