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Obesity is associated with many life-threatening diseases, including (but not limited to) diabetes, cancer, hormonal issues, stroke and cardiovascular disease

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S., Brcic L., et al
However, Instead of a single change point, they reported three slopes resulting in two change points and three subgroups

2.2.1 Oxidative stress and mitochondrial dysfunction METH significantly increases the production of ROS and reactive nitrogen species, overwhelming antioxidant defenses in neurons