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1,13,14 Metformin, an insulin-sensitizing agent, is a second-line treatment option for metabolic concerns when oral contraceptives and lifestyle changes do not provide satisfactory results

[DOI] [PMC free article] [PubMed] [Google Scholar] 263.Zeng X., Yang J., Hu O., Huang J., Ran L., Chen M., Zhang Y., Zhou X., Zhu J., Zhang Q., et al

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A previous review on OOT for knee OA reinforced this finding, suggesting that while short to medium-term results were encouraging, the included RCTs exhibited discernible methodological constraints [8]