Frontiers
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Phase I metabolism also involves cytochrome P450 (CYP) enzymes, particularly CYP3A4, which is the most prevalent hepatic enzyme and plays a key role in metabolizing dietary phytochemicals like curcumin (109111)
here, fibroblasts are the main target in contrast to keratinocytes in sunscreens
doi: 10.1016/S0300-483X(01)00471-1
Others mention that the packaging, while secure, occasionally arrives with minor dents or cosmetic imperfections
