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Conversely, the prevalence of alcohol abuse is approximately fourfold higher among individuals with nicotine dependence [76]

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That "one-third get neuro effects" figure is exactly the responder-subgroup signal a real trial is built to quantify

doi: 10.1038/cdd.2017.159 17 GuizeRLiuVMRosebrockDJourdainAAHernndez-SnchezMMartinez ZuritaAet al
