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Similarly, abnormal aggregated proteins such as -synuclein (-SYN) cannot be cleared or transported in time due to abnormal BBB function, and then deposit in the brain, exerting toxic effects on nerve cells and promoting the progression of the PD (Wang H

Hum Psychopharmacol 25:530535

While early stages of HCC can often be treated with curative therapies or locoregional therapies, more than half of all patients with HCC develop advanced stage HCC and are eligible for systemic therapy

It might also collect toxins from external factors through diet or environment

Of these BDNF has received considerable attention regarding depression and stress [58] and AD [55,59,60]