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In the brain, neurons have the highest energy requirements, but they cannot produce and store glucose, and therefore require a continuous supply of glucose to neurons via sodium-dependent glucose cotransporter family proteins (SGLT1 and SGLT2) and sodium-independent glucose transporter proteins (GLUT) across the BBB (8385)

10.1074/jbc.ra118.001764 J

Conclusion When combined thoughtfully, berberine and metformin dont cancel each other out, they complement each other

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