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AIF is a protein located within the mitochondria, whose activation leads to a caspase-independent pathway of apoptosis by mediating DNA fragmentation and chromatin condensation [49]

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As noted in this study, the complex action of BPC 157 tends to rule out a simple effect of either the vasoconstrictor (L-NAME) or the vasodilator (L-arginine)[3] in the noted rapid presentation of blood vessels that bypass the two obstructions of major vessels and reestablishing the blood flow that was interrupted by ligation in rats which subjected to the ischemic colitis procedure