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Current evidence remains largely correlative or derived from preclinical models

Additionally, mTOR could inhibit apoptosis and promote angiogenesis, thus playing a crucial role in folliculogenesis ( 2 O 2 -induced oxidative stress and autophagy levels in FGCs, via the PI3K/AKT/mTOR signaling pathway (Xu et al., 2022)

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butyrate, a short-chain fatty acid produced by Roseburia intestinalis , has been associated with improved anti-PD-1 efficacy against colorectal cancer (CRC) in mouse models [102]

After removing the membrane and organelle fraction, the pellet was washed 3X with 100L MIB before resuspending the cytoskeletal and nuclear fraction in 125 L Cytoskeletal and Nuclear Isolation Buffer