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Specific groups of people need to take vitamin B12 shots, such as Vegetarians and Vegans, older adults, individuals with gastrointestinal conditions, people with pernicious anaemia, pregnant and breastfeeding women, and individuals with symptoms of deficiency

Strong AHAs and BHAs increase penetration and can cause excessive irritation when combined with copper peptides

J Biol Chem 2010;285:2345723465

Safety depends on: Personal medical history Thyroid cancer history Pancreatitis history GI sensitivity Cardiovascular risk profile Both carry boxed warnings regarding thyroid C-cell tumors observed in animal studies