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Patients typically report fluctuating, widespread dull or aching pain, which may also include neuropathic characteristics such as burning or tingling

90 Of particular significance is the pivotal involvement of podocyte metabolic reprogramming in driving its development

It is not licensed in the UK and is currently available only through clinical trials

In physiological pH range of body fluid, over 99% of LA is dissociated into lactate anions (La ) and protons (H + ) [62], so lactate (not LA) is then transported into the extracellular space

Tyrosine phosphorylation of mitochondrial pyruvate dehydrogenase kinase 1 is important for cancer metabolism