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However, it has been described that chronic antigen stimulation can lead to mitochondrial hyperpolarization as shown in tumor-infiltrating lymphocytes in human renal cell carcinoma, also associated with increased ROS levels (43)

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Further in the pseudotime progression, cells still expressed Pax7 and Myf5 , but they also expressed cycling markers such as Cdk1/ Cdk 4

Targeting CD38 in vivo blocks mitochondrial transfer and improves animal survival in mice, demonstrating a consistently reduced tumor burden in bone marrows [26]

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