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Finally, inhibition of GGT activity deprives tumours of cysteine and slows their growth

Conflicting results for transplant-related mortality were obtained when the myeloablative regimen was changed from busulfan and cyclophosphamide to treosulfan, fludarabine and thiotepa (TreoFluT), and this change did not improve GVHD and graft failure in mixed-class groups of patients [87], [88]

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mtDNA is 10 times more vulnerable to mutations and oxidative stress than nDNA due to a lack of histones protection, fewer repair enzymes, and increased susceptibility to supercoiling damage [94]

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