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For example, the use of ALDH2 activators may accelerate the detoxification of 4-HNE and reduce cellular damage [130, 147]

ODonnell P, Grace AA

Cells 12(4):611 Li J et al (2023) The crosstalk between ferroptosis and mitochondrial dynamic regulatory networks

doi: 10.1016/j.ejphar.2011.04.038

Finally, prospects for ferroptosis-based interventions and future directions point to several promising treatment avenues, including regulating iron homeostasis via chelators or TfR1/FPN modulation, using antioxidants and lipid peroxidation inhibitors to target GPX4 and ACSL4, or employing gene therapies and stem cell/exosome approaches to combat ferroptosis