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Those are tiny sacs filled up with fluid containing biologically-specific content
The sequestration of the nondeformable spherocytes in the spleen and their subsequent phagocytosis by the splenic macrophages is responsible for anemia and splenomegaly

Pereira, G., et al

Interestingly, however, we found that Ghsr-null mice ate larger meals and had decreased feeding frequency 19

ASNS knockout reduces maximal biomass production rate to 57%, while CMPK1 knockout is lethal
