what is glutathione transferases Transferase - an overview Glutathione S-Transferases: Structure, Functions and

26 In addition, the activity of the cytochrome P450 reductase (POR) also requires NADPH, which has a major role in the metabolism of drugs, xenobiotics, and steroid hormones

doi:10.1159/000341583 Lee, Jeong Soo et al

Studies indicate that in uterine fibroids, interleukin-1 concentrations correlate positively with nuclear factor kappa-light-chain-enhancer of activated B cells (NF-B) levels, suggesting that inflammatory factors drive inflammatory responses and the fibrotic process by activating the NF-B signaling pathway [99]

doi:10.3109/15360288.2010.536306

In other words, the 1 in 10 people getting worse after starting with the B12 shots may just be the result of one of the other coexisting illnesses getting worse