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This transport process does not depend on ATP but is driven by the concentration difference of Glu or cystine on both sides of the membranes

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The mechanism most relevant to MS and its animal model, EAE, involves S1P 1 receptor signaling in astrocytes, which has been demonstrated in conditional null mouse mutants lacking S1P 1 in astrocytes
demonstrated that mitochondrial ROS are essential for necroptosis execution

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