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Concordantly, FXR-deficient mice exhibit hepatic steatosis with elevated intrahepatic triglyceride (TG) accumulation and hyperlipidemia characterized by increased serum TG and cholesterol levels [25]

If the pKa values are separated enough, three general plateaus, each centered at the pKa value of the ionizable group, can be seen in their titration curves

Sade-Feldman M, Yizhak K, Bjorgaard SL, Ray JP, de Boer CG, et al

Antibiotic disruption of the gut microbiota enhances the murine hepatic dysfunction associated with a high-salt diet

Gut microbiome dysbiosis similarly contributes to endometriosis pathogenesis through multiple mechanisms