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Clinical trials have shown that GDNF does not significantly improve motor symptoms in PD patients and is associated with a higher incidence of serious adverse events (179)

Despite its therapeutic potential, rhIGF-1 encounters several clinical limitations, primarily due to its structural homology with insulin, which may lead to hypoglycemia and growth hormone (GH) suppression (Jozefiak et al., 2021)

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Kavanagh JJ, Spriggs D, Bookman M, Ozols R, Gershenson DM, Han J, Lewis L, Brown GL, Dombrowski J, Maack C, Macpherson J, Lane A, Woodrow P and Henner WD

[DOI] [PMC free article] [PubMed] [Google Scholar] 99.Hurd T.R., Requejo R., Filipovska A., Brown S., Prime T.A., Robinson A.J., Fearnley I.M., Murphy M.P