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Effects of genistein on Nrf2/HO-1 pathway in myocardial tissues of diabetic rats

Evolution of insulin-like growth factor-I (IGF-1) action: in vitro characterization of vertebrate IGF-1 proteins

H 2 O 2 produced during the oxidative folding of endoplasmic reticulum proteins has been found to regulate the signal transduction process of nuclear factor E2-related factor 2 (Nrf2), which in turn regulates the expression of downstream glutathione peroxidase 8 (GPX8), which in turn can participate in ER calcium regulation through endoplasmic reticulum calcium ATPase (SERCA) (Granatiero et al., 2019) (Figure 7)

Symptom-based models replicate the typical motor symptoms of PD by rapidly inducing dopaminergic neuron damage through chemical or physical means, such as 6-hydroxydopamine (6-OHDA), MPTP, and rotenone models