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Since gastrointestinal disorders such as inflammatory bowel disease can interfere with the absorption of B12, measuring B12 levels in your cats blood can be a good indicator of overall gut health
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While losing some lean mass during aggressive weight loss is expected, this ratio is favorable compared to diet-only approaches where lean mass losses can reach 30-40%

After an initial round of closely spaced injections, patients can often go for a shot just once a month, instead of taking a daily supplement

A nasal spray is also available but is not considered the best treatment for severe deficiency because B12 is not absorbed as well as it is via injection
