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AD typically manifests in individuals over the age of 65, although earlyonset forms of the disease can occur in younger individuals

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The development of new strategies, including immune tolerance induction and vector engineering, may help overcome existing limitations [157]

Elderly patients, who may have lower metabolic efficiency, could experience slower collagen deposition partly due to less robust proline biosynthesis, making nutritional support important (e.g., supplementation with proline-rich gelatin or vitamin C to aid proline hydroxylation) [41]

So, while organ transplants save lives, they also put patients at higher risk for infections and degenerative diseases in the long term