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Moreover, at the border of bone tissue and muscle, there was granulation tissue, disorganized formation of bone tissue, and islands of bone tissue (presumed to be appositional growth) without contact with bone (Figure 16)

Stimulation of Angiogenesis: BPC-157 promotes the formation of new blood vessels by activating the VEGF (vascular endothelial growth factor) and nitric oxide (NO) signaling pathways

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Our results are also consistent with publications showing that CAV-1 reduction upregulates angiogenesis-related factors as evidenced by an inverse correlation between CAV-1 and VEGF in osteosarcoma 28 , increased CXCR12 expression in CAV-1 silenced fibroblast 29 , and a significant negative correlation between osteopontin and caveolin-1 levels in human osteoarthritic cartilage 30