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Description
Available from: pmid:2833557 36

The emergence of jawed vertebrates (gnathostomes) approximately 450 million years ago marked the first appearance of the full molecular repertoire of the adaptive immune system, including T and B cells, antibodies, and MHC molecules (Flajnik and Kasahara, 2010
A novel trivalent cation chelator Feralex dissociates binding of aluminum and iron associated with hyperphosphorylated tau of Alzheimers disease

Wang T, Dong Y, Huang Z, Zhang G, Zhao Y, Yao H, et al

Theres research showing, quite a few research papers, that aluminum is directly associated with slowing this gene down
