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Polyphenols possess antioxidant, anti-inflammatory, and anticancer properties, which contribute to the prevention of aging-related diseases such as cancers, nephrosclerosis, arthritis, and neurodegenerative and cardiovascular diseases (Arora et al., 2020)

Classification based on subcellular location GSTs can be categorized into cytosolic, mitochondrial, microsomal, or membrane-associated isoforms, based on their sub-cellular location

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Erythrivarines J-N and erythrivarines O-Z are alkaloids isolated from the peel of Erythrina variegata L., and studies have shown that erythrivarine N and erythrivarine T have neuroprotective effects on neomycin-induced hearing loss [231, 232]

Thus, Gsx1 and Gsx2 appear to be particularly sensitive to Pax6, as Gsx2 is to Dmrt factors (Konno et al., 2019)