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Archived from the original on October 16, 2012

Mitochondrial metabolism and KRASMAPK axis in CRC chemoresistance Although chemotherapeutic agents such as 5-FU, oxaliplatin, and irinotecan remain central to CRC treatment, the metabolic adaptability of tumor cells continues to undermine their long-term efficacy [23]
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Similar to breast cancer, lung cancer is also known to have LOH and reduced expression of GPx-1, suggesting that decreased intracellular GPx-1 activity may contribute to malignant transformation