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The relentless immune activity seen in Long COVID and ME/CFS generates an enormous amount of reactive oxygen species (ROS), leading to severe, systemic oxidative stress

While oxidative injury plays a dominant role in GSH depletion in many of these disorders, some are causally related to reduced expression of GSH synthetic enzymes [13]

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Hypoxia promotes glycogen accumulation through hypoxia inducible factor (HIF)-mediated induction of glycogen synthase 1

To make the medicine more effective and for general health benefits, stop smoking, maintain a healthy weight, and do not drink too much alcohol