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It has been shown only the R-form is used by mitochondrial alpha-keto acid dehydrogenases

The multifaceted roles of fatty acid synthesis in cancer

9 , 10 , 16 18 All subjects with cataract were required to meet the following inclusion criteria: (1) cataract in one or both eyes with best-corrected visual acuity of 20/40 or worse in one or both eyes as indicated by the medical record

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In a study of adjunctive therapy for complex partial seizures in which patients were receiving either carbamazepine or phenytoin in addition to valproate, no adjustment of carbamazepine or phenytoin dosage was needed [see Clinical Studies (14.2)]