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NAD+ levels decline 15-65% with age across tissues , triggering DNA damage, mitochondrial dysfunction, and cellular senescence that accelerate aging processes

Disorders that affect the gastrointestinal pH can also result in malabsorption and thus vitamin B 12 deficiency

Other populations at risk include people who had gastrointestinal surgery (including weight loss surgery) and diseases that affect the gut, such as Crohn's disease or celiac disease

Int J Epidemiol 47:1314g

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