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Metabolic messengers: fibroblast growth factor 15/19

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It plays a crucial role in the transport of fatty acids into the mitochondria of cells, where they are converted into energy

Results KAT6A mutations cause a decrease in histone H3 lysine 23 (H3K23) acetylation in human cells and mice To determine the effects of mutation of the KAT6A gene on histone acetylation, we generated human HEK293T cells carrying six different KAT6A variants observed in individuals with ARTHS using CRISPR/Cas9 and homology-directed repair (Tables S1, S2, and S3)

Therefore, during spinal cord hemisection, these axons will undergo intramedullary lesion, a very proximal type of axonal injury leading to rapid retrograde death of corresponding motoneurons [37], [38]