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This matters because it argues against simple collagen accumulation

Because of its high quality, the CDC also recommends using distilled water in humidifiers, CPAP machines and even nasal rinses

However, an imbalance between ROS production and antioxidant defense mechanisms can lead to oxidative stress, a pathological state linked to diseases like cancer and neurodegeneration [9]

Kong et al., 2022)
Note that the FDA has approved many peptide drugs over the years more generally including insulin