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This study suggested that oxaliplatin disrupts the extracellular glutamate homeostasis in the spinal cord resulting in CINP-induced behavior, and prophylactic riluzole may decrease oxaliplatin-induced mechanical allodynia [329]

Furthermore, Gln, but not Glu, supplementation enhances glucose tolerance and lowers mean arterial blood pressure in mice [19]

in a subset of the European Male Ageing Study cohort, showing a correlation between chronic widespread pain and low vitamin D in men at baseline [102]

Discussion Pancreatic ADM has been well described at the transcriptional level 47 and previous work has suggested that ROS levels can determine the fate of acinar cells

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