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However, excessive melanin deposition can ...

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The incidence and expression level of ATM correlated with pigmentary status in canities-affected hair follicles

Frequency groupings are classified according to the subsequent conventions: very common (1/10), Common (1/100 to <1/10), Uncommon (1/1,000 to <1/100), Rare (1/10,000 to <1/1,000), Very rare (<1/10,000) and Not known (cannot be estimated from the available data)
