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270 In an inflammatory response, activation of epithelial and immune cells triggers NOXs to generate ROS, which can directly kill microorganisms

Interleukin-1 inhibits leydig cell steroidogenesis primarily by decreasing 17 alpha-hydroxylase/C17-20 lyase cytochrome P450 expression

doi: 10.1155/2015/324581

This reaction is reported at a rate of around 70 cases per million doses of the vaccine

Masuda, Y., Murai, S., Saito, H., et al