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Low levels colonization of TMA-producing bacteria resulted in a significant accumulation of plasma TMAO in germ-free mice (Romano et al., 2015)

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Hepatic CD4 + helper T cells (Th1, 2, 17, and Tfh cells) stimulate allergic responses, cytokine release, and B cell proliferation [125]
Also, it crosses the blood-brain barrier (BBB) more effortlessly than regular L- Carnitine