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In women with polycystic ovary syndrome (PCOS)a condition sharing features with perimenopause such as insulin resistance and androgen excessNAC supplementation has been shown to lower testosterone, improve follicle-stimulating hormone (FSH) levels, and enhance ovulation.[5] While direct studies in perimenopausal women are limited, these findings suggest NAC may help support hormonal balance and metabolic health during the menopause transition.[6] 4

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PMID 6548969

2025;247:173919 Zamberletti E, Gabaglio M, Woolley-Roberts M, Bingham S, Rubino T, Parolaro D

Long COVID: to investigate immunological mechanisms and sex/gender related aspects as fundamental steps for tailored therapy