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Oksidatif Stresle Mcadele: Vcudumuz her gn milyonlarca hcresel ilem gerekletirir

Polyunsaturated fatty acids undergo nonenzymatic peroxidation when oxygen radicals generated by mitochondrial ROS production remove a hydrogen atom from the lipid, resulting in a lipid radical that can propagate to generate more peroxyl/alkoxyl radicals and hydroperoxide [83]

During cancer development and metastasis, tumor cells acquire enhanced invasiveness and migratory capabilities through EMT ( Tumor cells with high ZEB1 expression exhibit heightened dependence on GPX4, as GPX4 counteracts the oxidative effects of intracellular peroxides on PUFAs in cellular membranes, thereby attenuating ferroptosis

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