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300,303 Based on evidence that melatonin and melatonin receptors play an important role in anxiety, a melatonin-like drug, agomelatine, has been proposed as an emerging therapy for anxiety disorders (see section on Novel and Emerging Therapies)

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As described above, studies of murine models deficient in HSL have confirmed the importance of HSL for breakdown of DAG

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For patients with severe hepatic impairment (Child-Pugh Class C) , Esomeprazole metabolism is significantly reduced and plasma concentrations are substantially elevated