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4-HNE can form covalent bonds with proteins, DNA, and phospholipids, thereby disrupting cellular functions and playing a role in the pathogenesis of various diseases [144]

Worse wheezing right after starting a dose (paradoxical bronchospasm): This is rare but serious

Cellular immunology of relapsing multiple sclerosis: interactions, checks, and balances

Supplementary Table 7 )

6 Effects of metformin on gynecologic malignancies 6.1 Ovarian cancer Based on population-based retrospective studies and meta-analysis, there is a markedly reduced risk of ovarian cancer incidence associated with metformin use by patients with T2DM (Tseng, 2015