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doi: 10.1097/00000658-198511000-00016

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Most of the HTN-I patients had a combination treatment (ACE inhibitor + statin), which has been reported to have antioxidant effects (Profumo et al., 2014)

Moreover, p53 serves as a critical mediator to affect the activity of system XC- by downregulating SLC7A11 transcription and augmenting the expression of spermine/spermidine-n1-acetyltransferase 1, raising the level of ALOX15 and boosting the accumulation of cytoplasmic peroxides (Ou et al., 2016

Novel propargyl-linked bisubstrate analogues as tight-binding inhibitors for nicotinamide N-methyltransferase
