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This system is disrupted through pink-1 loss-of-function wherein mitochondrial fragmentation occurs due to reduced capacity for stress-induced autophagy and potentially leads to protein damage and, in neuronal compartments, neurodegeneration

Precursors are then transported into cells through unspecific ENTs, such as members of the SLC29A family for NR, while NMN requires dephosphorylation into NR before import into the cell by ENTs 68

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Patients should have no contraindications to hormonal therapy: This includes evaluating the patients medical history for contraindications to progestins or other hormonal treatments (35)