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In contrast, GCLC inhibition exerted a minimal impact on the growth of PDX tumors with low ACTL6A expression (cases 2 and 4) tumors (Fig

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It has also been shown to treat ulcers, heal inflammatory bowel disease as well as the upper and lower GI tract with remarkable efficiency

A very small minority of the cAP harvested from cells is active, and we have shown that this background activity primarily derives from a small fraction that, despite the absence of the N-terminal leader sequence, is nevertheless exported and oxidized by the periplasmic disulfide-bond forming system (Dsb) (Eben and Imlay, 2023)

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