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When animals were treated with 5 to more than 200 times the dose of what is relevant for humans, there were no histopathological changes in the different tissues and organs tested and no signs of deleterious or disruptive changes in blood biochemistry [94,97,117,118]

Also, mice carrying a genetic mutation that lack one of the igf1r alleles ( igf1r +/ ) show a 10 % reduction in post-natal growth, insulin resistance and glucose intolerance [237]

doi: 10.1097/GCO.0000000000000464 45 KobayashiHYoshimotoCMatsubaraSShigetomiHImanakaS

doi: 10.1002/jmv.27405 181 MarM.de GregorioE.de DiosC.Roca-AgujetasV.CucarullB.TutusausA.et al

The FDA does not conduct clinical trials or attempt to discover new treatments, but rather requires companies or other entities to fund marketing approvals