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When combined with 2-DG, CAI enhances the anticancer effect of 2-DG and has a dual inhibitory effect on energy production

To further confirm Nrf2s involvement in the ER calcium regulation process via GPX8, in the same study, after silencing Nrf2 in HeLa cells, GPX8 mRNA and protein levels also decreased, resulting in elevated ER and cytosolic calcium levels at rest and increased histamine-induced ER calcium release (Granatiero et al., 2019)

Most published data comes from animal and laboratory studies, and human clinical trials are lacking, so human efficacy is not established [1]

21 Impaired detoxification of reactive metabolites via a deficiency in glutathione, cysteine, and ascorbate, may play a role, and theoretically supports the use of glutathione precursors (NAC, SAMe) and vitamin C in treatment