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Genital lesions, especially those occurring in the vulva, often show more prominent atypical features, such as moderate to severe cytologic atypia (epithelioid cells with prominent nucleoli) and occasional pagetoid spread

These mutants were biochemically analyzed, revealing an altered topology of the Ca 2+ -binding site, thus proposing the role of this region of CRP in its binding to A, with the authors ultimately concluding that CRP is a dual pattern recognition molecule and an antiamyloidogenic protein as well [126]

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