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Description
This SC layer forms the principal barrier to drug permeation, largely due to its unique lipid composition, predominantly ceramides, cholesterol, fatty acids, and cholesteryl sulfate, arranged in bilayer structures within intercellular spaces [48, 223225]

S.JeongJ

Alemtuzumab is US Food and Drug Administration (FDA)-approved for the treatment of B cell chronic lymphocytic leukaemia (B-CLL) [19] and multiple sclerosis [20] and is being explored as a lymphodepleting agent in conditioning regimens, primarily to reduce the incidence of GvHD

Vitamin D deficiency can impair regulatory T-cell function and promote the activation of proinflammatory T helper (Th)1 and Th17 cells, resulting in an enhanced autoimmune response

AM designed the experiments and wrote the manuscript