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Long-read sequencing of an advanced cancer cohort resolves rearrangements, unravels haplotypes, and reveals methylation landscapes

Sparc-related modular calcium-binding protein 1 (SMOC1) has been identified as a glucose-responsive hepatokine that modulates dynamic glucose homeostasis by enhancing glycaemic control and insulin sensitivity independently of insulin secretion [197]

440,441,442 This process can be viewed as a two-phase mechanism: initial senescence induction followed by immune-mediated clearance

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