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This pathway is considered the most genotoxic as the 4-OH estrogen metabolites can become reactive quinones that have the potential to bind to DNA and form damaging (unstable) depurating adducts, that may increase risk for cancer, such as breast and prostate cancer

Hepatic mitochondrial glutathione: Transport and role in disease and toxicity

Insulin-like growth factor-1, insulin-like growth factor-binding protein-3, and breast cancer risk: observational and Mendelian randomization analyses with ~430 000 women

[DOI] [PubMed] [Google Scholar] 215.Loeser RF, Pacione CA, and Chubinskaya S, The combination of insulin-like growth factor 1 and osteogenic protein 1 promotes increased survival of and matrix synthesis by normal and osteoarthritic human articular chondrocytes

The full results of treatment are typically visible about a month or two after treatment, although multiple treatment sessions may be necessary to deliver the desired results